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The function of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which plays a vital regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also market cancer cell anoik

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